Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8.

Experimental gerontology - 1 Dec 2017

Liu Hung-Wen, Chan Yin-Ching, Wei Chu-Chun, Chen Yun-An, Wang Ming-Fu, Chang Sue-Joan

Abstract excerpt

Rodent animal models take at least 18months to develop aging phenotypes for researchers to investigate the mechanism of age-related metabolic complications. Senescence-accelerated mouse prone 8 (SAMP8) shortens the process of aging and may facilitate an alternative model for studying age-related insulin resistance. The short-lived strain SAMP8 and two long-lived strains SAM resistant 1 (SAMR1) mice and C57BL/6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipocytes
Share to Adipokines
Share to Cellular Senescence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dyslipidemias

Share to Energy Metabolism

Share to Inflammation Mediators

Share to Intra-Abdominal Fat

Share to Mice, Inbred AKR

Source

Identifiers

PMID: 28843510
DOI: 10.1016/j.exger.2017.08.023

Genes

IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An alternative model for studying age-associated metabolic complications: Senescence-accelerated mouse prone 8.PMID 28843510Read ↗

Adiposity-related biochemical phenotype in senescence-accelerated mouse prone 6 (SAMP6).Semantic proximity Read ↗

Phenotypic Aging and Sexual Dimorphism in C57BL/6J, SAMR1, and SAMP8 Mice: A Comparative Study.Semantic proximity Read ↗

Age-dependent tissue expression patterns of Sirt1 in senescence-accelerated miceSemantic proximity Read ↗

Senescence-accelerated mouse (SAM): a biogerontological resource in aging research.Semantic proximity Read ↗

Long-Term Feeding of a High-Fat Diet Ameliorated Age-Related Phenotypes in SAMP8 Mice.Semantic proximity Read ↗

Adiposity-Independent Effects of Aging on Insulin Sensitivity and Clearance in Humans and MiceSemantic proximity Read ↗

Loss of Pla2r1 decreases cellular senescence and age‐related alterations caused by aging and Western dietsSemantic proximity Read ↗

Biomarkers of oxidative stress, antioxidant defence and inflammation are altered in the senescence-accelerated mouse prone 8.Semantic proximity Read ↗

Senescence-accelerated mouse (SAM): a novel murine model of accelerated senescence.Semantic proximity Read ↗

Hypertriglyceridemia and hepatic steatosis in senescence-accelerated mouse associate to changes in lipid-related gene expression.Semantic proximity Read ↗

A novel murine model of aging, Senescence-Accelerated Mouse (SAM)Semantic proximity Read ↗

Experimental Induction of Type 2 Diabetes in Aging-Accelerated Mice Triggered Alzheimer-Like Pathology and Memory DeficitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.