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Article

Sexual dimorphism in lipid metabolic phenotype associated with old age in Sprague-Dawley rats.

Experimental gerontology - 1 Sept 2004

Sanguino E, Bejarano R, Alegret M, Sánchez R M, Vázquez-Carrera M, Laguna J C

Abstract excerpt

PURPOSE: Aged male rats show a decrease in liver PPARalpha. We aimed to determine if the sexual dimorphism in lipid metabolism observed in the PPARalpha-/- mouse is also present in senescent rats. RESULTS: Eighteen-month old rats were obese and presented high plasma NEFA concentrations. Old male rats were more hypercholesterolemic and hyperleptinemic than females, presenting a higher content in hepatic...

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Source

Identifiers

PMID: 15489052
DOI: 10.1016/j.exger.2004.06.007

Genes

DGAT1
DGAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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