Article

Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by Aging

2025-07-28

Abstract excerpt

Aging is associated with increased susceptibility to metabolic stress and chronic liver disease, yet the interactions between age and metabolic stressors and the potential for ameliorating interventions remain incompletely understood. Here, we examined the hepatic response of young (7-month-old) and old (25-month-old) C57BL/6 male mice to a 9-week high-fat diet (HFD) and assessed whether rapamycin, a well-establis...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4994d118-35ae-5ee5-b502-a28e772e0a97
DOI: 10.1101/2025.07.25.666837

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by AgingDOI 10.1101/2025.07.25.666837Read

Sex- and age-associated factors drive the pathophysiology of MASLDSemantic proximity Read

Aging promotes inflammation and steatosis in alcohol-associated liver disease in miceSemantic proximity Read

Rapamycin extends murine lifespan but has limited effects on aging.Semantic proximity Read

Functional and multi-omic aging rejuvenation with GLP-1R agonismSemantic proximity Read

Modulation of metabolic, inflammatory, fibrotic and cell death pathways by Resmetirom in metabolic dysfunction-associated steatohepatitis (MASH): A transcriptomic profiling studySemantic proximity Read

Hepatic loss of AATF attenuates MASH by suppressing AKT–mTORC1 signaling and reprogramming lipid metabolismSemantic proximity Read

Systematic transcriptomics analysis of calorie restriction and rapamycin unveils their synergistic interaction in prolonging cellular lifespanSemantic proximity Read

Role of Maraviroc and/or Rapamycin in Aging Liver ProcessesSemantic proximity Read

Calorie restriction and life-extending mutation downregulate miR-34a to facilitate lipid metabolism in the liver.Semantic proximity Read

A combination of the geroprotectors trametinib and rapamycin is more effective than either drug aloneSemantic proximity Read

Exercise alleviates liver senescence but does not outmatch the effect of dietary restriction in diet-induced MASLDSemantic proximity Read

Single‐cell transcriptome analysis of aging mouse liverSemantic proximity Read