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Article

PohnB6F1: a cross of wild and domestic mice that is a new model of extended female reproductive life span.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Nov 2007

Flurkey Kevin, Brandvain Yaniv, Klebanov Simon, Austad Steven N, Miller Richard A, Yuan Rong, Harrison David E

Abstract excerpt

In the search for novel genetic diversity that affects the timing of life history traits, we investigated a wild-derived stock of mice (Pohn). Early generations showed extended reproductive life span; however, this phenotype diminished with propagation of the stock. Out-crossing latter generation Pohn mice to C57BL/6J (B6) mice produced PohnB6F1 hybrids with remarkably extended reproductive life spans-mean age at...

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PMID: 18000137
DOI: 10.1093/gerona/62.11.1187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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