Article
Exotic mice as models for aging research: polemic and prospectus by R. Miller et al.
Neurobiology of aging - 1 Jan 2000
McClearn G E
Abstract excerpt
Miller and colleagues present a polemic against uniform genotypes in gerontological research and a paean for genetically heterogeneous populations. Both on simple sampling considerations, and because of selective loss of alleles through inbreeding depression, inbred strains are idiosyncratic, and the lack of genetic variance within strains limits their utility in examining relationships among phenotypes....
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