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Article

Characterization of adult hippocampal neurogenesis in adult and aged genetically diverse mice.

GeroScience - 1 Feb 2026

Finch Adele E, McNamara Avery D, Onos Kristen D, Keezer Kelly J, Howell Gareth R, Webb Ashley E

Abstract excerpt

Adult hippocampal neurogenesis-the generation of new neurons in the adult brain-declines with age, contributing to cognitive deficits in aging. While the majority of mammalian studies on neurogenesis have utilized inbred mouse strains, these models do not fully capture the genetic diversity of humans, limiting the translational relevance of their findings. The Diversity Outbred (DO) mouse model, a genetically...

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PMID: 40526250
DOI: 10.1007/s11357-025-01749-9
PMCID: PMC12972464

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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