Article
Exotic mice as models for aging research: polemic and prospectus.
Neurobiology of aging - 1 Jan 2000
Miller R A, Austad S, Burke D, Chrisp C, Dysko R, Galecki A, Jackson A, Monnier V
Abstract excerpt
Most gerontological research using rodent models employs inbred strains, or F1 hybrids derived from them, rather than populations of genetically heterogeneous individuals. This study presents the argument that reliance on genetically homogeneous rodents, though sanctioned by tradition, may not be ideal for many sorts of investigations, and that use of heterogeneous mice and rats would allow researchers to reach...
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