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Maximum life spans in mice are extended by wild strain alleles.

Experimental biology and medicine (Maywood, N.J.) - 1 Oct 2001

Klebanov S, Astle C M, Roderick T H, Flurkey K, Archer J R, Chen J, Harrison D E

Abstract excerpt

The genes that control basic aging mechanisms in mammals are unknown. By using two four-way crosses, each including a strain derived from wild, undomesticated stocks, we identified two quantitative trait loci that extend murine life spans by approximately 10%. In one cross, the longest-lived 18%...

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PMID: 11568309
DOI: 10.1177/153537020122600908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11568309-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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