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Article

Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Oct 2006

Harper James M, Durkee Stephen J, Dysko Robert C, Austad Steven N, Miller Richard A

Abstract excerpt

Previously we showed that mouse stocks derived from wild-caught progenitors are long-lived relative to genetically heterogeneous mice derived from laboratory-adapted strains. Here we replicate this life-span effect, and show that F2 hybrids between wild-derived and laboratory-derived stocks have intermediate survival patterns. Moreover, wild-derived mice are small, lean, and slow to mature, and have low serum...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17077194
DOI: 10.1093/gerona/61.10.1019
PMCID: PMC2766814

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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