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Article

Zebrafish Mef2ca and Mef2cb are essential for both first and second heart field cardiomyocyte differentiation.

Developmental biology - 15 Sept 2012

Hinits Yaniv, Pan Luyuan, Walker Charline, Dowd John, Moens Cecilia B, Hughes Simon M

Abstract excerpt

Mef2 transcription factors have been strongly linked with early heart development. D-mef2 is required for heart formation in Drosophila, but whether Mef2 is essential for vertebrate cardiomyocyte (CM) differentiation is unclear. In mice, although Mef2c is expressed in all CMs, targeted deletion of Mef2c causes lethal loss of second heart field (SHF) derivatives and failure of cardiac looping, but first heart...

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Source

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Identifiers

PMID: 22750409
DOI: 10.1016/j.ydbio.2012.06.019
PMCID: PMC3927553

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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