Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

NR1 knockdown reveals CA1 injury during a developmental period of high seizure susceptibility despite reduced seizure activity.

Neuromolecular medicine - 1 Jan 2007

Kaur J, Keesey R, Magrys B, Liu H, Friedman L K

Abstract excerpt

NMDA receptors (NMDARs) are important for the propagation of seizures. To understand the role of NR1 subunits in the propagation of seizures we knocked down the NR1 subunit by intracranial injection of antisense deoxyoligonucleotides (NR1-AS-ODNs) into the right hippocampus during a window of maximal seizure susceptibility in development. Control missense and sense ODNs followed by focal injection of NMDA (2.5-25...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium
Share to Electroencephalography
Share to Hippocampus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Neurons

Share to Pyramidal Cells

Share to Rats, Sprague-Dawley

Share to Receptors, N-Methyl-D-Aspartate

Share to Seizures

Source

Identifiers

PMID: 17999204
DOI: 10.1007/s12017-007-8009-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

NR1 knockdown reveals CA1 injury during a developmental period of high seizure susceptibility despite reduced seizure activity.PMID 17999204Read ↗

NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility.Semantic proximity Read ↗

Role of the hippocampus in Nav1.6 (Scn8a) mediated seizure resistance.Semantic proximity Read ↗

Early postnatal CA3 hyperexcitability drives hippocampal development and epileptogenesis in SCN2A developmental and epileptic encephalopathySemantic proximity Read ↗

New insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndromeSemantic proximity Read ↗

Modeling and treating <i>GRIN2A</i> developmental and epileptic encephalopathy in miceSemantic proximity Read ↗

NR1 knockdown mice as a representative model of the glutamate hypothesis of schizophrenia.Semantic proximity Read ↗

Reduced dendritic arborization and hyperexcitability of pyramidal neurons in a Scn1b-based model of Dravet syndrome.Semantic proximity Read ↗

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes.Semantic proximity Read ↗

Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a genetic model of NMDA receptor hypofunction.Semantic proximity Read ↗

Hippocampal CA1-region-restricted knockout of NMDAR1 gene disrupts synaptic plasticity, place fields, and spatial learning.Semantic proximity Read ↗

Defective excitatory/inhibitory synaptic balance and increased neuron apoptosis in a zebrafish model of Dravet syndromeSemantic proximity Read ↗

Altered GluN2A levels reduce the emergence of seizure-like events in a rat model of <i>GRIN2A</i> haploinsufficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.