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Article

NMDA-induced seizures in developing rats cause long-term learning impairment and increased seizure susceptibility.

Epilepsy research - 1 Feb 2003

Stafstrom Carl E, Sasaki-Adams Deanna M

Abstract excerpt

N-methyl-D-aspartate (NMDA) receptors play a prominent role in the pathogenesis of epilepsy, yet few studies have used NMDA as a convulsant in whole animals. In developing rats, systemic NMDA induces seizures with a unique seizure phenotype ("emprosthotonic" or hyperflexion seizures) and electrographic pattern (electrodecrement). These features are not seen in kainic acid-induced seizures, suggesting that...

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Identifiers

PMID: 12576174
DOI: 10.1016/s0920-1211(02)00258-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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