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Article

Gene expression signatures affected by alcohol-induced DNA methylomic deregulation in human embryonic stem cells

12 Apr 2014

Abstract excerpt

Stem cells, especially human embryonic stem cells (hESCs), are useful models to study molecular mechanisms of human disorders that originate during gestation. Alcohol (ethanol, EtOH) consumption during pregnancy causes a variety of prenatal and postnatal disorders collectively referred to as fetal alcohol spectrum disorders (FASDs). To better understand the molecular events leading to FASDs, we performed a...

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PMID: 24751885
DOI: 10.1016/j.scr.2014.03.009

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