Article
Mind bomb 1 is required for pancreatic β-cell formation.
Proceedings of the National Academy of Sciences of the United States of America - 8 May 2012
Horn Signe, Kobberup Sune, Jørgensen Mette C, Kalisz Mark, Klein Tino, Kageyama Ryoichiro, Gegg Moritz, Lickert Heiko, Lindner Jill, Magnuson Mark A, Kong Young-Yun, Serup Palle, Ahnfelt-Rønne Jonas, Jensen Jan N
Abstract excerpt
During early pancreatic development, Notch signaling represses differentiation of endocrine cells and promotes proliferation of Nkx6-1(+)Ptf1a(+) multipotent progenitor cells (MPCs). Later, antagonistic interactions between Nkx6 transcription factors and Ptf1a function to segregate MPCs into distal Nkx6-1(-)Ptf1a(+) acinar progenitors and proximal Nkx6-1(+)Ptf1a(-) duct and β-cell progenitors. Distal cells are...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.