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Article

NeuroD1 in the endocrine pancreas: Localization and dual function as an activator and repressor

19 May 2005

Abstract excerpt

The basic helix-loop-helix transcription factor NeuroD1 regulates cell fate in the nervous system but previously has not been considered to function similarly in the endocrine pancreas due to its reported expression in all islet cell types in the newborn mouse. Because we found that NeuroD1 potently represses somatostatin expression in vitro, its pattern of expression was examined in both strains of mice in which...

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Identifiers

PMID: 15906379
DOI: 10.1002/dvdy.20443

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NeuroD1 in the endocrine pancreas: Localization and dual function as an activator and repressorPMID 15906379Read ↗

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Neuronatin, a downstream target of BETA2/NeuroD1 in the pancreas, is involved in glucose-mediated insulin secretion.Semantic proximity Read ↗

Distinct Gene Expression Programs Function in Progenitor and Mature Islet CellsSemantic proximity Read ↗

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