Article
Ena/VASP Is Required for neuritogenesis in the developing cortex.
Neuron - 8 Nov 2007
Kwiatkowski Adam V, Rubinson Douglas A, Dent Erik W, Edward van Veen J, Leslie Jonathan D, Zhang Jiangyang, Mebane Leslie M, Philippar Ulrike, Pinheiro Elaine M, Burds Aurora A, Bronson Roderick T, Mori Susumu, Fässler Reinhard, Gertler Frank B
Abstract excerpt
Mammalian cortical development involves neuronal migration and neuritogenesis; this latter process forms the structural precursors to axons and dendrites. Elucidating the pathways that regulate the cytoskeleton to drive these processes is fundamental to our understanding of cortical development. Here we show that loss of all three murine Ena/VASP proteins, a family of actin regulatory proteins, causes neuronal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.