Article
Paxillin Is Required for Proper Spinal Motor Axon Growth into the Limb.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 Apr 2021
Tsai Wan-Ling, Chang Chih-Ju, Wang Chih-Yang, Hsu Tsung-I, Chang Ming-Yuan, Wu Yi-Hsin, Chang Pei-Shan, Lin Kai-Lun, Chuang Jian-Ying, Kania Artur, Kao Tzu-Jen
Abstract excerpt
To assemble the functional circuits of the nervous system, the neuronal axonal growth cones must be precisely guided to their proper targets, which can be achieved through cell-surface guidance receptor activation by ligand binding in the periphery. We investigated the function of paxillin, a focal adhesion protein, as an essential growth cone guidance intermediary in the context of spinal lateral motor column...
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