Article
Filopodia are required for cortical neurite initiation.
Nature cell biology - 1 Dec 2007
Dent Erik W, Kwiatkowski Adam V, Mebane Leslie M, Philippar Ulrike, Barzik Melanie, Rubinson Douglas A, Gupton Stephanie, Van Veen J Edward, Furman Craig, Zhang Jiangyang, Alberts Arthur S, Mori Susumu, Gertler Frank B
Abstract excerpt
Extension of neurites from a cell body is essential to form a functional nervous system; however, the mechanisms underlying neuritogenesis are poorly understood. Ena/VASP proteins regulate actin dynamics and modulate elaboration of cellular protrusions. We recently reported that cortical axon-tract formation is lost in Ena/VASP-null mice and Ena/VASP-null cortical neurons lack filopodia and fail to elaborate...
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