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Article

Mena is required for neurulation and commissure formation.

Neuron - 1 Feb 1999

Lanier L M, Gates M A, Witke W, Menzies A S, Wehman A M, Macklis J D, Kwiatkowski D, Soriano P, Gertler F B

Abstract excerpt

Mammalian enabled (Mena) is a member of a protein family thought to link signal transduction pathways to localized remodeling of the actin cytoskeleton. Mena binds directly to Profilin, an actin-binding protein that modulates actin polymerization. In primary neurons, Mena is concentrated at the tips of growth cone filopodia. Mena-deficient mice are viable; however, axons projecting from interhemispheric...

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Identifiers

PMID: 10069337
DOI: 10.1016/s0896-6273(00)81092-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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