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Article

Tight junction protein occludin regulates progenitor Self-Renewal and survival in developing cortex.

eLife - 3 Dec 2019

Bendriem Raphael M, Singh Shawn, Aleem Alice Abdel, Antonetti David A, Ross M Elizabeth

Abstract excerpt

Occludin (OCLN) mutations cause human microcephaly and cortical malformation. A tight junction component thought absent in neuroepithelium after neural tube closure, OCLN isoform-specific expression extends into corticogenesis. Full-length and truncated isoforms localize to neuroprogenitor centrosomes, but full-length OCLN transiently localizes to plasma membranes while only truncated OCLN continues at...

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Source

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Identifiers

PMID: 31794381
DOI: 10.7554/eLife.49376
PMCID: PMC6890460

Genes

OCLN
RAN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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