Article
Gene deletion mutants reveal a role for semaphorin receptors of the plexin-B family in mechanisms underlying corticogenesis.
Molecular and cellular biology - 1 Feb 2010
Hirschberg A, Deng S, Korostylev A, Paldy E, Costa M R, Worzfeld T, Vodrazka P, Wizenmann A, Götz M, Offermanns S, Kuner R
Abstract excerpt
Semaphorins and their receptors, plexins, are emerging as key regulators of various aspects of neural and nonneural development. Semaphorin 4D (Sema4D) and B-type plexins demonstrate distinct expression patterns over critical time windows during the development of the murine neocortex. Here, analysis of mice genetically lacking plexin-B1 or plexin-B2 revealed the significance of Sema4D-plexin-B signaling in...
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