Article

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiation

2022-06-19

Abstract excerpt

<h4>Summary</h4> Pyramidal neurons are the major cell type of the forebrain, consisting of a pyramidally shaped soma with axonal and apicobasal dendritic processes. It is poorly understood how the neuronal soma morphs from a sphere to pyramid, while generating neurites of the proper shape and orientation. Here, we discovered that the spherical somata of immature neurite-less neurons possess a circumferential wrea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 94f4199d-4d53-5832-98a6-8ffef18b1b03
DOI: 10.1101/2022.06.19.496721

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Pyramidal neuron morphogenesis requires a septin network that stabilizes filopodia and suppresses lamellipodia during neurite initiationDOI 10.1101/2022.06.19.496721Read

A dual shaping mechanism for postsynaptic ephrin-B3 as a receptor that sculpts dendrites and synapses.Semantic proximity Read

Axon initial segments: structure, function, and diseaseSemantic proximity Read

Interregional human assembloids recapitulate fetal brain morphologies and enhance neuronal complexitySemantic proximity Read

Increased proximal bifurcation of CA1 pyramidal apical dendrites in sema3A mutant mice.Semantic proximity Read

The GTP-binding protein Septin 7 is critical for dendrite branching and dendritic-spine morphology.Semantic proximity Read

A phosphatidylinositol lipids system, lamellipodin, and Ena/VASP regulate dynamic morphology of multipolar migrating cells in the developing cerebral cortex.Semantic proximity Read

A functional role for Septin-2 in the maintenance of the axon initial segment and in human cognitive development.Semantic proximity Read

Ena/VASP Is Required for neuritogenesis in the developing cortex.Semantic proximity Read

Integrin β3 organizes dendritic complexity of cerebral cortical pyramidal neurons along a tangential gradient.Semantic proximity Read

Ontogenesis of the pyramidal cell of the mammalian neocortex and developmental cytoarchitectonics: a unifying theory.Semantic proximity Read

Cytokinesis and postabscission midbody remnants are regulated during mammalian brain development.Semantic proximity Read

Neuron-enriched phosphatase and actin regulator 3 (Phactr3)/ nuclear scaffold-associated PP1-inhibiting protein (Scapinin) regulates dendritic morphology via its protein phosphatase 1-binding domain.Semantic proximity Read