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Article

The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts.

Neuropsychobiology - 1 Jan 2007

Reuter Martin, Hennig Juergen, Amelang Manfred, Montag Christian, Korkut Tatjana, Hueweler Anja, Stürmer Til

Abstract excerpt

Based on pharmacological and genetic studies suggesting a role of the serotonergic system for nicotine dependence, two genetic variants, one on the tryptophan hydroxylase 1 (TPH1) and one on the TPH2 gene, were investigated. The TPH2 -703G/T promoter polymorphism was associated with smoking status and age of smoking onset in two independent Caucasian samples of different age cohorts. Sample 1 consisted of 3,602...

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Source

Identifiers

PMID: 17986837
DOI: 10.1159/000110728

Genes

TPH1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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