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Article

TPH2 and TPH1: association of variants and interactions with heroin addiction.

Behavior genetics - 1 Mar 2008

Nielsen David A, Barral Sandra, Proudnikov Dmitri, Kellogg Scott, Ho Ann, Ott Jurg, Kreek Mary Jeanne

Abstract excerpt

The tryptophan hydroxylase 2 gene (TPH2) was resequenced at the 5' upstream, coding, and 3' downstream regions, including all 11 exons in 185 subjects. Twenty-three novel and 14 known variants were identified. In a cohort of 583 consecutively ascertained subjects, including normal volunteers and those with specific addictive diseases, six common TPH2 and one TPH1 variant were genotyped. Allele frequencies of...

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Source

Identifiers

PMID: 18181017
DOI: 10.1007/s10519-007-9187-7

Genes

TPH2
TPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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TPH2 and TPH1: association of variants and interactions with heroin addiction.PMID 18181017Read ↗

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Exploring the Roles of 5-HTTLPR, STin2, 5-HT2A, and TPH2 Variants in Heroin DependenceSemantic proximity Read ↗

The role of the TPH1 and TPH2 genes for nicotine dependence: a genetic association study in two different age cohorts.Semantic proximity Read ↗

SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.Semantic proximity Read ↗

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.Semantic proximity Read ↗

Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese.Semantic proximity Read ↗

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