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Article

The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42.

The Journal of biological chemistry - 21 Dec 2001

Sokol S Y, Li Z, Sacks D B

Abstract excerpt

IQGAP1 contains a number of protein recognition motifs through which it binds to targets. Several in vitro studies have documented that IQGAP1 interacts directly with calmodulin, actin, E-cadherin, beta-catenin, and the small GTPases Cdc42 and Rac. Nevertheless, direct demonstration of in vivo function of mammalian IQGAP1 is limited. Using a novel assay to evaluate in vivo function of IQGAP1, we document here...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11584017
DOI: 10.1074/jbc.M107975200

Genes

IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The effect of IQGAP1 on Xenopus embryonic ectoderm requires Cdc42.PMID 11584017Read ↗

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Role of IQGAP1, a target of the small GTPases Cdc42 and Rac1, in regulation of E-cadherin- mediated cell-cell adhesion.Semantic proximity Read ↗

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The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes.Semantic proximity Read ↗

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