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Article

Crystal structure of the GTPase-activating protein-related domain from IQGAP1.

The Journal of biological chemistry - 29 May 2009

Kurella Vinodh B, Richard Jessica M, Parke Courtney L, Lecour Louis F, Bellamy Henry D, Worthylake David K

Abstract excerpt

IQGAP1 is a 190-kDa molecular scaffold containing several domains required for interaction with numerous proteins. One domain is homologous to Ras GTPase-activating protein (GAP) domains. However, instead of accelerating hydrolysis of bound GTP on Ras IQGAP1, using its GAP-related domain (GRD) binds to Cdc42 and Rac1 and stabilizes their GTP-bound states. We report here the crystal structure of the isolated...

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Identifiers

PMID: 19321438
DOI: 10.1074/jbc.M808974200
PMCID: PMC2685667

Genes

IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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