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Article

Exploring the sequence space of a DNA aptamer using microarrays.

Nucleic acids research - 1 Jan 2007

Katilius Evaldas, Flores Carole, Woodbury Neal W

Abstract excerpt

The relationship between sequence and binding properties of an aptamer for immunoglobulin E (IgE) was investigated using custom DNA microarrays. Single, double and some triple mutations of the aptamer sequence were created to evaluate the importance of specific base composition on aptamer binding. The majority of the positions in the aptamer sequence were found to be immutable, with changes at these positions...

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Identifiers

PMID: 17981839
DOI: 10.1093/nar/gkm922
PMCID: PMC2190713

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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