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Article

Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression.

Immunity - 1 Nov 2007

Naito Taku, Gómez-Del Arco Pablo, Williams Christine J, Georgopoulos Katia

Abstract excerpt

Lineage commitment is induced by changes in gene expression dictated by the intimate interaction between transcription factors and chromatin regulators. Here, we revealed the antagonistic interplay between Ikaros and its associate the chromatin remodeler Mi-2beta during T cell development, as exemplified by the regulation of Cd4 expression. Loss of Ikaros or Mi-2beta led to activation or repression, respectively,...

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Share to Adenosine Triphosphatases
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to DNA Helicases

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Share to Silencer Elements, Transcriptional

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Source

Identifiers

PMID: 17980631
DOI: 10.1016/j.immuni.2007.09.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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