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Article

Transcriptional circuits in B cell transformation

29 Apr 2017

Abstract excerpt

PURPOSE OF REVIEW: Loss of IKAROS in committed B cell precursors causes a block in differentiation while at the same time augments aberrant cellular properties, such as bone marrow stromal adhesion, self-renewal and resistance to glucocorticoid-mediated cell death. B cell acute lymphoblastic leukaemias originating from these early stages of B cell differentiation and associated with IKAROS mutations share a...

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PMID: 28463873
DOI: 10.1097/moh.0000000000000352

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