Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.

European journal of immunology - 1 Feb 2013

Collins Bernard, Clambey Eric T, Scott-Browne James, White Janice, Marrack Philippa, Hagman James, Kappler John W

Abstract excerpt

Ikaros is important in the development and maintenance of the lymphoid system, functioning in part by associating with chromatin-remodeling complexes. We have studied the functions of Ikaros in the transition from pre-T cell to the CD4(+) CD8(+) thymocyte using an Ikaros null CD4(-) CD8(-) mouse thymoma cell line (JE131). We demonstrate that this cell line carries a single functional TCR β gene rearrangement...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Proteins, Non-Histone
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to Homeodomain Proteins

Share to Ikaros Transcription Factor

Share to Receptors, Antigen, T-Cell, alpha-beta

Share to Thymoma

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23172374
DOI: 10.1002/eji.201242757
PMCID: PMC3923402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ikaros promotes rearrangement of TCR α genes in an Ikaros null thymoma cell line.PMID 23172374Read ↗

The CD8alpha gene locus is regulated by the Ikaros family of proteins.Semantic proximity Read ↗

A dominant mutation in the Ikaros gene leads to rapid development of leukemia and lymphoma.Semantic proximity Read ↗

IKAROS regulates human T cell phenotype at a thymic and postthymic level.Semantic proximity Read ↗

The ikaros gene is required for the development of all lymphoid lineagesSemantic proximity Read ↗

Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.Semantic proximity Read ↗

Lack of Ikaros cripples expression of Foxo1 and its targets in naive T cells.Semantic proximity Read ↗

Ikaros, Helios, and Aiolos protein levels increase in human thymocytes after β selection.Semantic proximity Read ↗

Transcriptional regulation of the Ikzf1 locusSemantic proximity Read ↗

Antagonistic interactions between Ikaros and the chromatin remodeler Mi-2beta determine silencer activity and Cd4 gene expression.Semantic proximity Read ↗

Lack of Ikaros Deregulates Inflammatory Gene Programs in T CellsSemantic proximity Read ↗

Ikaros sets thresholds for T cell activation and regulates chromosome propagation.Semantic proximity Read ↗

Ikaros is absolutely required for pre-B cell differentiation by attenuating IL-7 signals.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.