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Article

Ikaros Directly Represses the Notch Target Gene Hes1 in a Leukemia T Cell Line

21 Feb 2008

Abstract excerpt

Ikaros and Notch1, two regulators of gene transcription, are critically important at many stages of T cell development. Deregulation of Ikaros and Notch activities cooperate to promote T cell leukemogenesis, providing evidence that they function in converging pathways in developing T cells. In this report, a mechanism for Ikaros:Notch cooperativity is described, revealing a non-redundant role for Ikaros in...

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PMID: 18287091
DOI: 10.1074/jbc.m709643200

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