Article
Analysis of a spindle pole body mutant reveals a defect in biorientation and illuminates spindle forces.
Molecular biology of the cell - 1 Jan 2005
Yoder Tennessee J, McElwain Mark A, Francis Susan E, Bagley Joy, Muller Eric G D, Pak Brian, O'Toole Eileen T, Winey Mark, Davis Trisha N
Abstract excerpt
The spindle pole body (SPB) is the microtubule organizing center in Saccharomyces cerevisiae. An essential task of the SPB is to ensure assembly of the bipolar spindle, which requires a proper balancing of forces on the microtubules and chromosomes. The SPB component Spc110p connects the ends of the spindle microtubules to the core of the SPB. We previously reported the isolation of a mutant allele spc110-226...
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