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Article

RGD delivery of truncated coagulase to tumor vasculature affords local thrombotic activity to induce infarction of tumors in mice.

Scientific reports - 15 Aug 2017

Jahanban-Esfahlan Rana, Seidi Khaled, Monhemi Hassan, Adli Amir Daei Farshchi, Minofar Babak, Zare Peyman, Farajzadeh Davoud, Farajnia Safar, Behzadi Ramezan, Abbasi Mehran Mesgari, Zarghami Nosratollah, Javaheri Tahereh

Abstract excerpt

Induction of thrombosis in tumor vasculature represents an appealing strategy for combating cancer. Herein, we combined unique intrinsic coagulation properties of staphylocoagulase with new acquired functional potentials introduced by genetic engineering, to generate a novel bi-functional fusion protein consisting of truncated coagulase (tCoa) bearing an RGD motif on its C-terminus for cancer therapy. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28811469
DOI: 10.1038/s41598-017-05326-9
PMCID: PMC5557930

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