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Article

Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma.

British journal of cancer - 19 Nov 2007

Hubner R A, Liu J-F, Sellick G S, Logan R F A, Houlston R S, Muir K R

Abstract excerpt

The effects of polymorphisms in genes coding for key folate metabolism enzymes such as thymidylate synthetase (TS) on colorectal neoplasia risk are likely to be influenced by gene-gene and gene-nutrient interactions. We investigated the combined effects of three polymorphisms in the TS gene region, TSER, TS 3R G>C, and TS 1494del6, dietary intakes of folate and other B vitamins, and genotype for other folate...

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Identifiers

PMID: 17971770
DOI: 10.1038/sj.bjc.6604056
PMCID: PMC2360236

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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