Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methionine synthase and thymidylate synthase gene polymorphisms and colorectal adenoma risk: the self defense forces study.

Molecular carcinogenesis - 1 Oct 2012

Yoshimitsu Shinichiro, Morita Makiko, Hamachi Tadamichi, Tabata Shinji, Abe Hiroshi, Tajima Osamu, Uezono Kousaku, Ohnaka Keizo, Kono Suminori

Abstract excerpt

Folate-mediated one-carbon metabolism has been implicated in colorectal carcinogenesis. We investigated associations of functional genetic polymorphisms of methionine synthase (MTR), MTR reductase (MTRR), and thymidylate synthase (TS) with colorectal adenomas. The study subjects were 455 cases of colorectal adenomas and 1052 controls with no polyp at colonoscopy. Genotypes were determined for MTR A2756G, MTRR...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alcohol Drinking

Share to Enhancer Elements, Genetic

Share to Ferredoxin-NADP Reductase

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Tandem Repeat Sequences

Share to Thymidylate Synthase

Source

Identifiers

PMID: 22407825
DOI: 10.1002/mc.21895

Genes

MTR
MTRR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methionine synthase and thymidylate synthase gene polymorphisms and colorectal adenoma risk: the self defense forces study.PMID 22407825Read ↗

Methionine synthase D919G polymorphism, folate metabolism, and colorectal adenoma risk.Semantic proximity Read ↗

Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas.Semantic proximity Read ↗

Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma.Semantic proximity Read ↗

Colorectal adenomas and the C677T MTHFR polymorphism: evidence for gene-environment interaction?Semantic proximity Read ↗

Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study.Semantic proximity Read ↗

Methylene tetrahydrofolate reductase genotype modifies the chemopreventive effect of folate in colorectal adenoma, but not colorectal cancer.Semantic proximity Read ↗

Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas.Semantic proximity Read ↗

DNA methyltransferase and alcohol dehydrogenase: gene-nutrient interactions in relation to risk of colorectal polyps.Semantic proximity Read ↗

Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the fukuoka colorectal cancer study.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.Semantic proximity Read ↗

The methylenetetrahydrofolate reductase 677C-->T polymorphism and distal colorectal adenoma risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.