Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Nov 2005

Ulrich Cornelia M, Curtin Karen, Potter John D, Bigler Jeannette, Caan Bette, Slattery Martha L

Abstract excerpt

Folate metabolism supports the synthesis of nucleotides as well as the transfer of methyl groups. Polymorphisms in folate-metabolizing enzymes have been shown to affect risk of colorectal neoplasia and other malignancies. Using data from a population-based incident case-control study (1,600 cases and 1,962 controls), we investigated associations between genetic variants in the reduced folate carrier (RFC),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Adenoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Folic Acid

Share to Membrane Transport Proteins

Share to Reduced Folate Carrier Protein

Share to Thymidylate Synthase

Source

Identifiers

PMID: 16284371
DOI: 10.1158/1055-9965.EPI-05-0261

Genes

MTHFR
MTR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer.PMID 16284371Read ↗

Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma.Semantic proximity Read ↗

Polymorphism in the thymidylate synthase promoter enhancer region modifies the risk and survival of colorectal cancer.Semantic proximity Read ↗

Methionine synthase and thymidylate synthase gene polymorphisms and colorectal adenoma risk: the self defense forces study.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer.Semantic proximity Read ↗

Folate-related nutrients, genetic polymorphisms, and colorectal cancer risk: the fukuoka colorectal cancer study.Semantic proximity Read ↗

Folate-genetics and colorectal neoplasia: what we know and need to know next.Semantic proximity Read ↗

Polymorphism in the thymidylate synthase promoter enhancer region and risk of colorectal adenomas.Semantic proximity Read ↗

Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) gene, intakes of folate and related B vitamins and colorectal cancer: a case-control study in a population with relatively low folate intake.Semantic proximity Read ↗

The association between two polymorphisms in the TS gene and risk of cancer: a systematic review and pooled analysis.Semantic proximity Read ↗

Plasma folate, related genetic variants, and colorectal cancer risk in EPIC.Semantic proximity Read ↗

Polymorphisms in genes involved in folate metabolism and colorectal neoplasia: a HuGE review.Semantic proximity Read ↗

Polymorphisms in methionine synthase, methionine synthase reductase and serine hydroxymethyltransferase, folate and alcohol intake, and colon cancer risk.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.