Article
Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma.
Cancer science - 1 Sept 2005
Kono Suminori, Chen Kun
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA methylation and synthesis. Two functional, common polymorphisms (C677T and A1298C) are known in the MTHFR gene. MTHFR activity is lowered in individuals with the 677TT genotype and is somew...
Topics
- Adenoma
- Colorectal Neoplasms
- Epidemiologic Studies
- Folic Acid
- Genetic Predisposition to Disease
- Genotype
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)
- Nutritional Status
- Polymorphism, Genetic