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Article

Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma.

Cancer science - 1 Sept 2005

Kono Suminori, Chen Kun

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA methylation and synthesis. Two functional, common polymorphisms (C677T and A1298C) are known in the MTHFR gene. MTHFR activity is lowered in individuals with the 677TT genotype and is somewhat reduced in those with the 1298CC genotype. We reviewed the consistency of reported associations of these...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Methylenetetrahydrofolate Reductase (NADPH2)

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Source

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Identifiers

PMID: 16128738
DOI: 10.1111/j.1349-7006.2005.00090.x
PMCID: PMC11160001

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic polymorphisms of methylenetetrahydrofolate reductase and colorectal cancer and adenoma.PMID 16128738Read ↗

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