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Epigenetic Silencing of Cyclooxygenase-2 Affects Clinical Outcome in Gastric Cancer

30 Oct 2007

Abstract excerpt

PURPOSE: Overexpression of cyclooxygenase-2 (COX-2) in gastric cancer has been shown to enhance tumor progression. We investigated whether silencing by promoter region hypermethylation of the COX-2 gene contributes to disease outcome in gastric cancer. MATERIALS AND METHODS: COX-2 methylation status was initially assessed by capillary array electrophoresis methylation-specific polymerase chain reaction (CAE-MSP)...

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Identifiers

PMID: 17971584
DOI: 10.1200/jco.2006.09.8921

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