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Article

Prostaglandin E2 induces DNA hypermethylation in gastric cancer in vitro and in vivo

1 Jan 2019

Abstract excerpt

Rationale: Prostaglandin E2 (PGE2) is a pro-inflammatory eicosanoid up-regulated in gastric cancer (GC). However, its impact on epigenetic dysfunction in the process of gastric carcinogenesis is unknown. In this study, we investigate the role of PGE2 in DNA methylation in gastric epithelium in vitro, in mice, and humans. Methods: PGE2-induced DNMT3B and DNA methylation was determined in gastric cell lines and...

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PMID: 31534549
DOI: 10.7150/thno.35766

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