Article
Correlation between cyclooxygenase-2, proliferative activity, and mucin phenotype in human advanced gastric cancer.
Journal of gastroenterology - 1 Dec 2004
Yamagishi Mariko, Noda Masao, Tatsumi Yoichi, Mukaisho Ken-ichi, Mitsufuji Shoji, Sugihara Hiroyuki, Okanoue Takeshi, Hattori Takanori
Abstract excerpt
BACKGROUND: Recent studies have suggested that nonsteroidal anti-inflammatory drugs (NSAIDs) reduce the risk of gastrointestinal cancer, and that cyclooxygenase-2 (COX-2) may be a target enzyme for the prevention or regression of cancer by the use of NSAIDs. Mucin histochemistry has made possible a clear distinction between the differentiated characteristics of gastrointestinal epithelial cells, and the...
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