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Article

Aberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.

Cancer research - 1 Aug 2000

Toyota M, Shen L, Ohe-Toyota M, Hamilton S R, Sinicrope F A, Issa J P

Abstract excerpt

Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of one of the COX isozymes, COX2, has been shown to play an important role in colorectal cancer progression. Recently, however, low expression of COX2 has been reported in a subset of colorectal and gastric cancers. Aberrant CpG island methylation and associated transcriptional silencing are common in colorectal...

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Share to CpG Islands
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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PMID: 10945606

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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