Article
Parkin localizes to the Lewy bodies of Parkinson disease and dementia with Lewy bodies.
The American journal of pathology - 1 May 2002
Schlossmacher Michael G, Frosch Matthew P, Gai Wei Ping, Medina Miguel, Sharma Nutan, Forno Lysia, Ochiishi Tomoyo, Shimura Hideki, Sharon Ronit, Hattori Nobutaka, Langston J William, Mizuno Yoshikuni, Hyman Bradley T, Selkoe Dennis J, Kosik Kenneth S
Abstract excerpt
Mutations in alpha-synuclein (alpha S) and parkin cause heritable forms of Parkinson disease (PD). We hypothesized that neuronal parkin, a known E3 ubiquitin ligase, facilitates the formation of Lewy bodies (LBs), a pathological hallmark of PD. Here, we report that affinity-purified parkin antibodies labeled classical LBs in substantia nigra sections from four related human disorders: sporadic PD, inherited...
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