Article
Incorporation of covariates into multipoint linkage disequilibrium mapping in case-control studies.
Genetic epidemiology - 1 Feb 2008
Chiu Yen-Feng, Liang Kung-Yee, Chuang Lee-Ming, Beaty Terri H
Abstract excerpt
Case-control designs are commonly adopted in genetic epidemiological studies because they are cost effective and offer powerful tests for genetic and environmental risk factors, as well as their interactions. Previously, we proposed an association mapping approach to estimate the position of an unobserved disease locus as well as measuring its genetic effect on risk. The method provides a confidence interval for...
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