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Loss of Complement Factor D suppresses alternative pathway activation but fails to reduce lipofuscin accumulation in the retinal pigmented epithelium of <i> Abca4 <sup>-/-</sup> </i> mice

2025-10-26

Abstract excerpt

Stargardt disease (STGD1) is the most common inherited macular dystrophy, caused by loss-of-function mutations in ABCA4 that result in bisretinoid-containing lipofuscin accumulation in the retinal pigment epithelium (RPE), and progressive photoreceptor degeneration. Oxidative stress and complement system activation have been implicated as contributors to disease pathogenesis, but the requirement for alternative p...

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Literature Corpus work
e7b2e54c-21bf-54dc-9bed-5357d9a93f1b
DOI
10.1101/2025.10.25.684461
Open publication

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Loss of Complement Factor D suppresses alternative pathway activation but fails to reduce lipofuscin accumulation in the retinal pigmented epithelium of <i> Abca4 <sup>-/-</sup> </i> miceDOI 10.1101/2025.10.25.684461
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