Article
HLA-E*0101 allele in homozygous state favors severe bacterial infections in sickle cell anemia.
Human immunology - 1 Oct 2007
Tamouza Ryad, Busson Marc, Fortier Catherine, Diagne Ibrahima, Diallo Dapa, Sloma Ivan, Contouris Hector, Krishnamoorthy Rajagopal, Labie Dominique, Girot Robert, Charron Dominique
Abstract excerpt
Severe bacterial infections are the major causes of morbidity and mortality in sickle cell anemia (SCA) but are poorly explained. The distribution of a bi-allelic polymorphism (Arg107Gly) of human leukocyte antigen-E (HLA-E) locus was investigated in 144 SCA patients, most of whom originated from from sub-Saharan Africa. Among them, 73 presented with at least one severe bacterial infection, whereas 71 did not....
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