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Article

Infectious complications in sickle cell disease are influenced by HLA class II alleles.

Human immunology - 1 Mar 2002

Tamouza Ryad, Neonato Maria Grazia, Busson Marc, Marzais François, Girot Robert, Labie Dominique, Elion Jacques, Charron Dominique

Abstract excerpt

Despite systematic antibiotic therapy, severe infections (septicemia, meningitis, or osteomyelitis) are a major cause of mortality and morbidity in children with sickle cell disease (SCD). In this study, we explored the possibility that polymorphism at the human leukocyte antigen (HLA) locus might constitute an immunogenetic modifying factor to the intrinsic susceptibility to infection in patients with SCD. A...

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Source

Identifiers

PMID: 11872237
DOI: 10.1016/s0198-8859(01)00378-0

Genes

SCD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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