Article
Allele frequency of Hemoglobin S among patients with uncomplicated Plasmodium falciparum malaria in N'Djamena, Chad.
Acta tropica - 1 Dec 2025
Yamti Suitombaye Noubaramadji, Akouya Amine, Dezoumbe Koutaya, Tawe Leabaneng, Kgakatsi Setho Ruth Taboka, Djibagaou Abel Dafogo, Routoubé Monique, Cappelli Giulia, Atturo Sabrina, Dongho Ghyslaine Bruna Djeunang, Russo Gianluca, Dzomo Guy Rodrigue Takoudjou, Colizzi Vittorio, Paganotti Giacomo Maria
Abstract excerpt
Protection against malaria induced by the sickle cell trait has been a major example of genetic selection for over half a century. It has been demonstrated that human populations in Africa have acquired a high frequency of haemoglobin S (HbS) allele because the heterozygous genotype (sickle cell trait) provides protection against the severe symptoms of Plasmodium falciparum infection leading to lower parasite...
Topics
- Humans
- Malaria, Falciparum
- Chad
- Hemoglobin, Sickle
- Female
- Gene Frequency
- Male
- Adult
- Young Adult
- Adolescent