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Hemoglobin E: a balanced polymorphism protective against high parasitemias and thus severe P falciparum malaria.

Blood - 15 Aug 2002

Chotivanich Kesinee, Udomsangpetch Rachanee, Pattanapanyasat Kovit, Chierakul Wirongrong, Simpson Julie, Looareesuwan Sornchai, White Nicholas

Abstract excerpt

Hemoglobin E is very common in parts of Southeast Asia. The possible malaria protective effects of this and other inherited hemoglobin abnormalities prevalent in Thailand were assessed in a mixed erythrocyte invasion assay. In vitro, starting at 1% parasitemia, Plasmodium falciparum preferentially invaded normal (HbAA) compared to abnormal hemoglobin (HbH, AE, EE, HCS, beta-thalassemia E) red cells (HRBCs). The...

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PMID: 12149194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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