Article
Homozygous status for HLA-E*0103 confers protection from acute graft-versus-host disease and transplant-related mortality in HLA-matched sibling hematopoietic stem cell transplantation.
Transplantation - 15 Dec 2006
Tamouza Ryad, Busson Marc, Rocha Vanderson, Fortier Catherine, Haddad Yacine, Brun Manuel, Boukouaci Wahid, Bleux Hélène, Socié Gérard, Krishnamoorthy Rajagopal, Toubert Antoine, Gluckman Eliane, Charron Dominique
Abstract excerpt
BACKGROUND: The posttransplant period following hematopoietic stem cell transplantation (HSCT) is potentially high risk for developing survival-compromising complications, many of which are known to be under the control of immunogenetic factors. Given the dual role of human leukocyte antigen (HLA)-E molecules in innate and adaptive immune processes, we analyzed the impact of HLA-E polymorphism in genoidentical...
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