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Article

HLA class II haplotypes distinctly associated with vaso-occlusion in children with sickle cell disease.

Clinical and vaccine immunology : CVI - 1 Apr 2008

Mahdi Najat, Al-Ola Khadija, Al-Subaie Abeer M, Ali Muhallab E, Al-Irhayim Zaid, Al-Irhayim A Qader, Almawi Wassim Y

Abstract excerpt

We investigated the association of HLA class II alleles and haplotypes with sickle cell anemia vaso-occlusive crisis (VOC). DRB1*100101 was positively associated, while DRB1*140101, DRB1*150101, and DQB1*060101 were negatively associated, with VOC. Both susceptible (DRB1*100101-DQB1*050101) and protective (DRB1*110101-DQB1*030101 and DRB1*150101-DQB1*060101) haplotypes were identified, indicating that HLA class...

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Share to Anemia, Sickle Cell
Share to Arterial Occlusive Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Constriction, Pathologic

Share to Endothelium, Vascular

Share to Erythrocytes, Abnormal

Share to HLA-DQ Antigens

Share to HLA-DQ beta-Chains

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Source

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Identifiers

PMID: 18272668
DOI: 10.1128/CVI.00425-07
PMCID: PMC2292664

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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